Zebrabiores

Zebrafish Research

• Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodelling.

  Moral-Sanz J., Fernández-Carrasco I., Ramponi V., Garrido A., Karbat I., Cabezas-Sáinz P., Rivera de Torre E., Elsallabi O., Martín-Hernández R., López-Aceituno J.L., Price N.L.,Sánchez L., Colmenarejo G., Martínez del Pozo A., Vetter I., Cogolludo A., Pérez-Vizcaino F., Del Pozo J., Reuveny E., Fernández-Rojo M.A., Robbins P.D., de Cabo R., Serrano M. & Ikonomopoulou M.P.

  Nature Aging, 6: 349-367 (doi: 10.1038/s43587-025-01030-w) 2026
   

  Modeling neuropsychiatric diseases and drugresponses in Zebrafish.

  Damiano A., Sánchez L. & Arana A.

  En: Zebrafish Model in Medical Research. Disner G.D. (Ed.) IntechOpen, London. 29pp. (https://www.intechopen.com/chapters/1225327) 2025

   

  Effects of two different peptides on pentylenetetrazole-induced seizures in larval zebrafish.

  Fernández J.A.A., de Moura T.C., Vila S.F., Gaytán J.A.R., López-Díaz I., Learte-Aymamí S., Vázquez M.E., Mayán M.D., Sánchez L. & Maurer-Morelli C.V.

  PLoS One, 20: e0308581 (doi: 10.1371/journal.pone.0308581) 2025

   

  Zebrafish models for congenital disorders of glycosylation (CDG): a systematic review.

  Gandoy-Fieiras N., Quiroga M.I. & Sánchez L.

  Orphanet Journal of Rare Diseases, 20: 484 (doi: 10.1186/s13023-025-04016-4) 2025

   

  Protamine-sased nanotherapeutics for gene delivery to glioblastoma cells

  Barrios-Esteban S., Reimóndez-Troitiño S., Cabezas-Sainz P., de la Fuente M., Sánchez L., Rahman R., Alexander C., Garcia-Fuentes M. & Csaba N.S.

  Molecular Pharmaceutics, 22: 2466-2481 (doi: 10.1021/acs.molpharmaceut.4c01269) 2025

   

  CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds.

  Amarilla-Quintana S., Navarro P., Ramos A., Montero-Calle A., Cabezas-Sáinz P., Barrero M.J., Megías D., Vilaplana-Martí B., Epifanio C., Gómez-Domínguez D., Hernández I., Monzón S., Cuesta I., Sánchez L., Barderas R., García-Donas J., Martín A. & Pérez de Castro I.

  Molecular Oncology, 19: 1092-1116 (doi: 10.1002/1878-0261.13799) 2025

   

  Designing polyphosphazene derivatives for gene delivery in glioblastoma treatment.

  García-Mazas C., Bozzato E., Araujo Fernández J.A., Quattrini F., Preat V., Sánchez L., Csaba N. & García-Fuentes M.

  Materials Today Bio, 33: 102010 (doi: 10.1016/j.mtbio.2025.102010) 2025

   

  Red blood cell-tumor cell interactions promote tumor cell progression.

  Pereira-Veiga T., Yáñez-Gómez C., Pekkarinen A., Abuín C., Blechner C., González-Conde M., Mess C., Vidal-Y-Sy S., Moustafa A., Siebels B., Dávila-Ibáñez A.B., Cabezas-Sainz P., Santos M., Sánchez L., Gorgulho J., Götze J., Meißner K., Cueva J., Palacios P., Cortegoso A., Curiel T., Rodríguez C., Carmona M., León-Mateos L., Abalo A., Muinelo-Romay L., Peine S., Schmidt M., Heuer-Olewinski N., Reck M., Abdo M., Lamszus K., Bauer A.T., López-López R., Pantel K., Windhorst S., Wikman H. &, Costa C.

  Journal of Experimental & Clinical Cancer Research, 44: 134 (doi: 10.1186/s13046-025-03376-w) 2025

   

  Comparative analysis of CRISPR/Cas9 delivery methods in marine Teleost cell lines.

  Arana A., Veiga-Rúa S., Cora D., González-Gómez M.A., Seijas A., Carballeda M., Polo D., Cuesta A., Piñeiro Y., Rivas J., Novo M., Al-Soufi W., Martínez P., Sánchez l. & Robledo D.

  International Journal of Molecular Sciences, 26: 10703 (doi: 10.3390/ijms262110703) 2025

   

  CRISPR/Cas9 delivery systems to enhance gene editing efficiency.

  Seijas A., Cora D., Novo M., Al-Soufi W., Sánchez L. & Arana A.J.

  International Journal of Molecular Sciences, 26: 4420 (doi: 10.3390/ijms26094420) 2025

   

  Emerging frontiers in zebrafish embryonic and adult-derived cell lines.

  Arana A.J., González-Llera L., Barreiro-Iglesias A. & Sánchez L.

  International Journal of Molecular Sciences, 26: 4351 (doi: 10.3390/ijms26094351) 2025

   

  Triazole-derived Ruthenium(II) complexes as novel candidates for cancer therapy.

  Lenis-Rojas O.A., Roma-Rodrigues C., Carvalho B., Andrade V., Friães S., Cabezas-Sáinz P., Araujo-Fernández J.A., Fernández Vila S., Arana A.J., Sánchez L., Baptista P.V., Gomes C.S.B., Fernandes A.R. & Royo B.

  ChemPlusChem, 2025: e202400775 (doi: 10.1002/cplu.202400775) 2025

   

  An in vivo drug screen reveals that Sirtuin 2 activity promotes spinal cord neurogenesis in developing zebrafish.

  González-Llera L., Arana A.J., Sánchez L. & Barreiro-Iglesias A.

  Biomolecules, 15: 1359 (doi: 10.3390/biom15101359) 2025

   

  Organization of serotonergic cell populations in the brain and spinal cord of the short-lived African turquoise killifish.

  González-Llera L., Arana A.J., Sánchez L., Anadón R. & Barreiro-Iglesias A.

  Biology (Basel), 14: 1206 (doi: 10.3390/biology14091206) 2025

   

  The toxicity of lead and lead-free perovskite precursors and nanocrystals to human cells and aquatic organisms.

  Maietta I., Otero-Martínez C., Fernández S., Sánchez L., González-Fernández A., Polavarapu L. & Simón-Vázquez R.

  Advanced Science, 12: 2415574 (doi: 10.1002/advs.202415574) 2025

   

  Identification of gene co-expression modules from zebrafish brain data: applications in psychiatry illustrated through alcohol-related traits.

  Al-Soufi L., Arana A.J., Facal F., Flórez G., Vázquez F.L., Arrojo M., The GenPol Study Group, Sánchez L. & Costas J.

  Progress in Neuro-Psychopharmacology & Biological Psychiatry, 135: 111136 (doi: 10.1016/j.pnpbp.2024.111136). 2024

   

  Reprogramming tubor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.

  Palencia-Campos A., Ruíz-Cañas L., Abal-Sanisidro M., López-Gil J.C., Batres-Ramos S., Mendes Saraiva S., Yagüe B., Navarro D., Alcalá S., Rubiolo J.A., Bidan N., Sánchez L., Mura S., Hermann P.C., de la Fuente M. & Sáinz B. Jr.

  Journal of Nanobiotechnology, 22: 795 (doi: 10.1186/s12951-024-03010-5) 2024.

   

  Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy.

  Alcalá S., Villarino L., Ruíz-Cañas L., Couceiro J.R., Martínez-Calvo M., Palencia-Campos A., Navarro D., Cabezas-Sáinz P., Rodríguez-Arabaolaza I., Cordero-Barreal A., Trilla-Fuertes L., Rubiolo J.A., Batres-Ramos S., Vallespinos M., González-Páramos C., Rodríguez J., Gámez-Pozo A. Fresno-Vara J.A., Fra-Fernández S., Benito-Berliches A., Moreno-Mata N., Torres Redondo A.M., Carrato A., Hermann P.C., Sánchez L., Torrente S., Fernández-Moreno M.A., Mascareñas J.L. & Sáinz Jr B.

  Journal of Experimental & Clinical Cancer Research, 43: 33 (doi: 10.1186/s13046-023-02931-7) 2024

   

  The peptidoglycan recognition protein 1 confers immune evasive properties on pancreatic cancer stem cells.

  López-Gil J.C., García-Silva S., Ruiz-Cañas L., Navarro D., Palencia-Campos A., Giráldez-Trujillo A., Earl J., Dorado J., Gómez-López G., Monfort-Vengut A., Alcalá S., Gaida M.M., García-Mulero S., Cabezas-Sáinz P., Batres-Ramos S., Barreto E., Sánchez-Tomero P., Vallespinos M., Ambler L., Lin M-L., Aicher A., García García de Paredes A., de la Pinta C., Sanjuanbenito A., Ruz-Caracuel I., Rodríguez-Garrote M., Guerra C., Carrato A., de Cárcer G., Sánchez L., Nombela-Arrieta C., Espinet E., Sánchez-Arévalo Lobo V.J., Heeschen C. & Sáinz Jr B.

  Gut, 73: 1489-1508 (doi: 10.1136/gutjnl-2023-330995) 2024

   

  Knockout, knockdown, and the Schrödinger paradox: Genetic immunity to phenotypic recapitulation in zebrafish.

  Arana A.J. & Sánchez L.

  Genes, 15(9): 1164 (doi: 10.3390/genes15091164) 2024

   

  Toxicity of zinc oxide nanoparticles: Cellular and behavioural effects.

  Fernández-Bertolez N., Alba-González A., Touzani A., Ramos-Pan L., Méndez J., Reis A.T., Quelle-Regaldie A., Sánchez L., Folgueira M., Laffon B. & Valdiglesias V.

  Chemosphere, 363: 142993 (doi: 10.1016/j.chemosphere.2024.142993) 2024

   

  An in vivo drug screen in zebrafish reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis.

  González-Llera L., Sobrido-Cameán D., Quelle-Regaldie A., Sánchez L. & Barreiro-Iglesias A.

  Cell Proliferation, 57: e13594 (doi: 10.1111/cpr.13594) 2024

   

  Isothermal calorimetry reveals that successful regeneration after a spinal cord injury in larval zebrafish is associated with an increase in energy expenditure.

  González-Llera L., Arana A.J., Sánchez L., Álvarez-Lorenzo C. & Barreiro-Iglesias.

  BBA-Bioenergetics, 1865: 149498 (doi: 10.1016/j.bbabio.2024.149498) 2024

   

  Severe neurometabolic phenotype in npc1 -/zebrafish with a C- terminal mutation.

  Quelle-Regaldie A., Gandoy-Fieiras N., Villamayor P.R., Maceiras As., Losada A.P., Folgueira M., Cabezas-Sáinz P., Barreiro-Iglesias A., Villar-López M., Quiroga M.I., Sánchez L. & Sobrido M.J.

  Frontiers in Cell and Developmental Biology, 11: 1076432 (https://doi.org/10.3389/fcell.2023.1076432) 2023

  
   

  Formulation and Characterization of Epalrestat-Loaded Polysorbate 60 Cationic Niosomes for Ocular Delivery.

  Kattar A., Quelle-Regaldie A., Sánchez L., Concheiro A. & Alvarez-Lorenzo C.

  Pharmaceutics , 15(4), 1247. (doi.org/10.3390/pharmaceutics15041247) 2023

  
   

  Modelling metastasis in zebrafish unveils regulatory interactions of cancer-associated fibroblasts with circulating tumour cells.

  Hurtado P., Martínez-Pena I., Yepes-Rodríguez S., Bascoy-Otero M., Abuín C., Fernández-Santiago C., Sánchez L., López-López R. & Piñeiro R.

  Frontiers in Cell and Developmental Biology, 11: 1076432 (https://doi.org/10.3389/fcell.2023.1076432) 2023

   

  Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury.

  De Sousa N., Robledo D., González-Llera L., Pinho A.G., Santos D.J., Monteiro S., Campos J., Cibrão J.R., Silva N.A., Sánchez L., Salgado A.J. & Barreiro-Iglesias A.

  Data in Brief, 46: 108809 (doi.org/10.1016/j.dib.2022.108809) 2023

  
   

  Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers.

  Martín A., Epifano C., Vilaplana-Marti B., Hernández I., Macías R.I.R., Martínez-Ramírez A., Cerezo A., Cabezas-Sáinz P., Garranzo-Asensio M., Amarilla-Quintana S., Gómez-Domínguez D., Caleiras E., Camps J., Gómez-López G., Gómez de Cedrón M., Ramírez de Molina A., Barderas R., Sánchez L., Velasco S. & Pérez de Castro I.

  Cell Death & Differentiation, 30: 37-53 ( doi.org/10.1038/s41418-022-01044-6) 2023

  
   

  A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry.

  March-Vila E., Ferretti G., Terricabras E., Ardao I., Brea J.M., Varela M.J., Arana A., Rubiolo J.A., Sanz F., Loza M.I., Sánchez L., Alonso H. & Pastor M.

  Archives of Toxicology (doi.org/10.1007/s00204-023-03459-7) 2023

  
   

  Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation.

  Gámez-Chiachio M., Molina-Crespo A., Ramos-Nebot C., Martínez-Val J., Martínez L., Gassner K., Llobet F.J., Soriano M., Hernández A., Cordani M., Bernadó-Morales C., Díaz E., Rojo-Sebastian A., Triviño J.C., Sánchez L., Rodríguez-Barrueco R., Arribas J., Llobet-Navás D., Sarrio D. & Moreno-Bueno G.

  Journal of Experiment and Clinical Cancer Research, 41: 285 (doi.org/10.1186/s13046-022-02497-w) 2022

  
   

  Manganese (I) tricarbonyl complexes as potential anticancer agents.

  Lenis-Rojas O.A., Carvalho B., Cabral R., Silva M., Friães S., Roma-Rodrigues C., Meireles S.H., Gomes C.S.B., Fernández J.A.A., Vila S.F., Rubiolo J.A., Sánchez L., Baptista P.V., Fernandes A.R. & Royo B.

  Journal of Biological Inorganic Chemistry, 27: 49-64 (doi.org/10.1007/s00775-021-01910-7) 2022

  
   

  Pluronic®/casein micelles for ophthalmic delivery of resveratrol: in vitro, ex vivo, and in vivo tests.

  Vivero-López M., Sparacino C., Quelle-Regaldie A., Sánchez L., Candal E., Barreiro-Iglesias A., Huete-Toral F., Carracedo G., Otero A., Concheiro A. & Alvarez-Lorenzo C.

  International Journal of Pharmaceutics, 628: 122281 (doi.org/10.1016/j.ijpharm.2022.122281) 2022

  
   

  In vitro and in vivo biological activity of ruthenium 1,10-phenanthroline-5,6-dione arene complexes.

  Lenis-Rojas O.A., Roma-Rodrigues C., Carvalho B., Cabezas-Sáinz P., Fernández-Vila S., Sánchez L., Baptista P.V., Fernandes A.R. & Royo B.

  International Journal of Molecular Sciences, 23: 13594 (doi.org/10.3390/ijms232113594) 2022

  
   

  Embryonic nutritional hyperglycemia decreases cell proliferation in the zebrafish retina.

  Hernández-Núñez I., Vivero-López M., Quelle-Regaldie A., DeGrip W.J., Sánchez L., Concheiro A., Alvarez-Lorenzo C., Candal E. & Barreiro-Iglesias A.

  Histochemistry and Cell Biology, 158: 401-409 (doi.org/10.1007/s00418-022-02127-8) 2022

  
   

  Zebrafish as a platform to evaluate the potential of lipidic nanoemulsions for gene therapy in cancer.

  Cascallar M., Hurtado P., Lores S., Pensado-López A., Quelle-Regaldie A., Sánchez L., Piñeiro R. & de la Fuente M.

  Frontiers in Pharmacology, 13: 1007018 (doi.org/10.3389/fphar.2022.1007018) 2022

  
   

  What zebrafish and nanotechnology can offer for cancer treatments in the age of personalized medicine.

  Cascallar M., Alijas S., Pensado-López A., Vázquez-Ríos A.J., Sánchez L., Piñeiro R. & de la Fuente M.

  Cancers, 14: 2238 (doi.org/10.3390/cancers14092238) 2022

  
   

  The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAFV600E.

  Moral-Sanz J., Fernandez-Rojo M.A., Colmenarejo G., Kurdyukov S., Brust A., Ragnarsson L., Andersson A., Vila S.F., Cabezas-Sainz P., Wilhelm P., Vela-Sebastián A., Fernández-Carrasco I., Chin Y.K.Y., López-Mancheño Y., Smallwood T.B., Clark R.J., Fry B.G., King G.F., Ramm G.A., Alewood P.F., Lewis R.J., Mulvenna J.P., Boyle G.M., Sánchez L.E., Neely G.G., Miles J.J. & Ikonomopoulou M.P

  British Journal of Pharmacology, 179: 4878-4896 (doi.org/10.1111/bph.15923) 2022

  
   

  A nop56 zebrafish loss of function model exhibits a severe neurodegenerative phenotype.

  Quelle-Regaldie A., Folgueira M., Yáñez J., Sobrido-Cameán D., Alba-González A., Barreiro-Iglesias A., Sobrido M.J. & Sánchez L.

  Biomedicines, 10: 1814 (doi.org/10.3390/biomedicines10081814) 2022

  
   

  A comprehensive structural, lectin and immunohistochemical characterization of the zebrafish olfactory system

  Villamayor P.R., Arana A.J., Coppel C., Ortiz-Leal I., Torres M.V., Sánchez-Quinteiro P. & Sánchez L. 2021.

  Scientific Reports, 11: 8865 (doi.org/10.1038/s41598-021-88317-1)

  
   

  Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model

  Saraiva S.M., Gutiérrez-Lovera C., Martínez-Val J., Lores S., Bouza B.L., Díez-Villares S., Alijas S., Pensado-López A., Vázquez-Ríos A.J., Sánchez L. & de la Fuente M. 2021.

  Scientific Reports, 11: 9873 (doi.org/10.1038/s41598-021-87968-4) 2021

  
   

  Zebrafish models to test new nanomaterials: focus on macrophages and therapeutic manipulation of the innate immune system.

  Pensado-López A., Fernández-Rey J., Reimunde P., Crecente-Campo J., Sánchez L. & Torres Andón F.

  Nanomaterials, 11: 1784 (doi.org/10.3390/nano11071784) 2021

   

   

  N-heterocyclic carbene iron complexes as anticancer agents: in vitro and in vivo biological studies.

  Lenis-Rojas O.A., Cordeiro S., Horta-Meireles M., Araujo-Fernández J.A., Fernández-Vila S., Rubiolo J.A., Cabezas-Sáinz P., Sánchez L., Fernandes A.R. & Royo B.

  Molecules, 26: 5535 (doi.org/10.3390/molecules26185535) 2021

  
   

  Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug.

  Alors-Pérez E., Blázquez-Encinas R., Alcalá S., Viyuela-García C., Pedraza-Arévalo S., Herrero-Aguayo V., Jiménez-Vacas J.M., Mafficini A., Sánchez-Frías M.E., Cano M.T., Abollo-Jiménez F., Marín-Sanz J.A., Cabezas-Sáinz P., Lawlor R., Sánchez L., Sánchez-Hidalgo J.M., Ventura S., Martin-Hijano L., Gahete M.D., Scarpa A., Arjona-Sánchez A., Ibáñez-Costa A., Sáinz Jr. B., Luque R.M. & Castaño J.P.

  Journal of Experimental & Clinical Cancer Research, 40: 382 (doi.org/10.1186/s13046-021-02153-9) 2021

  
   

  Decline in constitutive profilerative activity in the zebrafish retina with ageing.

  Hernández-Núñez I., Quelle-Regaldie A., Sánchez L., Adrio F., Candal E. & Barreiro-Iglesias A.

  International Journal of Molecular Science, 22: 11715. (doi.org/10.3390/ijms222111715) 2021

  
   

  Dissecting breast cancer circulating tumor cells competence via modelling metastasis in zebrafish.

  Martínez-Pena I., Hurtado P., Carmona-Ule N., Abuín C., Dávila-Ibáñez A.B., Sánchez L., Abal M., Chaachou A., Hernández-Losa J., Ramón y Cajal S., López-López R. & Piñeiro R.

  International Journal of Molecular Sciences, 22: 9279. (doi.org/10.3390/ijms22179279) 2021

  
   

  Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer.

  Lenis-Rojas O.A., Roma-Rodrigues C., Fernandes A.R., Carvalho A., Cordeiro S., Guerra-Varela J., Sánchez L., Vázquez-García D., López-Torres M., Fernández A. & Fernández J.J

  International Journal of Molecular Sciences, 22: 8916. (doi.org/10.3390/ijms22168916) 2021

   

  Triazole-based half-sandwich ruthenium(II) compounds: from in vitro antiproliferative potential to in vivo toxicity evaluation.

  Lenis-Rojas O.A., Cabral R., Carvalho B., Friães S., Roma-Rodrigues C., Araujo Fernández J.A., Fernández-Vila S., Sánchez L., Gomes C.S.B., Fernandes A.R., Fernandes A.R. & Royo B.

  Inorganic Chemistry, 60: 8011-8026. (doi.org/10.1021/acs.inorgchem.1c00527) 2021

  
   

  Conservation of zebrafish MicroRNA-145 and its role during neural crest cell development

  Steeman T.J., Rubiolo J.A., Sánchez L.E., Calcaterra N.B. & Weiner A.M.J. 2021.

  Genes 2021, 12(7), 1023; (https://doi.org/10.3390/genes12071023). 2021

   

  Morphological abnormalities and gene expression changes caused by high incubation temperaturas in zebrafish xenografts with human cancer cells

  Cabezas-Sáinz P., Coppel C., Pensado-López A., Fernández P., Muinelo-Romay L., López-López R., Rubiolo J.A. & Sánchez L

  Genes 12: 113. (doi.org/10.3390/genes12010113) 2021

   

  Loss of active neurogenesis in the adult shark retina.

  Hernández-Núñez I., Robledo D., Mayeur H., Mazan S., Sánchez L., Adrio F., Barreiro-Iglesias A. & Candal E.

  Frontiers in Cell and Developmental Biology, 9: 628721. doi: doi.org/10.3389/fcell.2021.628721) 2021

  
   

  Zebrafish models of autosomal recessive ataxias.

  Quelle-Regaldie A., Sobrido-Cameán D., Barreiro-Iglesias A., Sobrido M.J. & Sánchez L. 2021. Zebrafish models of autosomal recessive ataxias.

  Cells, 10: 836. (doi.org/10.3390/cells10040836) 2021

  
   

  Zebrafish models of autosomal dominant ataxias.

  Quelle-Regaldie A., Sobrido-Cameán D., Barreiro-Iglesias A., Sobrido M.J. & Sánchez L.

  Cells, 10: 421. (doi.org/10.3390/cells10020421) 2021

  
   

  Cellular and molecular mechanisms underlying glioblastoma and zebrafish models for the discovery of new treatments

  Reimunde P., Pensado-López A., Carreira Crende M., Lombao Iglesias V., Sánchez L., Torrecilla-Parra M., Ramírez C.M., Anfray C. & Torres Andón F.

  Cancers, 13: 1087. (doi.org/10.3390/cancers13051087) 2021

   

  Inhibition of mitochondrial dynamics preferentially targets pancreatic cancer cells with enhanced tumorigenic and invasive potential.

  Courtois S., de Luxán-Delgado B., Penin-Peyta L., Royo-García A., Parejo-Alonso B., Jagust P. Alcalá S., Rubiolo J.A., Sánchez L., Sáinz Jr. B., Heeschen C. & Sancho P.

  Cancers, 13: 698. (doi.org/10.3390/cancers13040698) 2021

  
   

  The multifaceted roles of gasdermins in cancer biology and oncologic therapies

  Sarrió D., Martínez-Val J., Molina-Crespo A., Sánchez L. & Moreno-Bueno G.

  BBA-Reviews on Cancer, 1876: 188635 (doi.org/10.1016/j.bbcan.2021.188635) 2021

  
   

  ZFTool: A software for automatic quantification of cancer cell mass evolution in zebrafish.

  Carreira M.J., Vila-Blanco N., Cabezas-Sáinz P. & Sánchez L.

  Applied Science, 11: 7721. (/doi.org/10.3390/app11167721) 2021.

   

  Experimental models to study Autism Spectrum Disorders hiPSCs, rodents and zebrafish.

  Pensado-López A., Veiga-Rúa S., Carracedo A., Allegue C. & Sánchez L.

  Genes, 11: 1376 (doi: 10.3390/genes11111376). 2020

   

  Circulating tumor cells characterization revealed TIMP1 as a bivek therapeutic target in ovarian cancer

  Abreu M., Cabezas-Sáinz P., Alonso-Alconada L., Ferreirós A., Mondelo-Macía P., Lago-Lestón R.M., Abalo A., Díaz E., Palacios-Zambrano S., Rojo-Sebastián A., López-López R., Sánchez L., Moreno-Bueno G. & Muinelo-Romay L.

  Cells, 9: 1218. (doi: 10.3390/cells9051218) 2020

   

  Exploiting oxidative phosphorylation to promete the stem and immunoevasive properties of pancreatic cancer stem cells

  Valle S., Alcalá S., Martin-Hijano L., Cabezas-Sáinz P., Navarro D., Ramos Muñoz E., Yuste L., Tiwary K., Walter K., Ruíz-Cañas L., Alonso-Nocelo M., Rubiolo J.A., González-Arnay E., Heeschen C., García-Bermejo L., Hermann P.C., Sánchez L., Sancho P., Fernández-Moreno M.A. & Sáinz B. Jr.

  Nature Communications, 11:5265 (https://doi.org/10.1038/s41467-020-18954-z) 2020

   

  Developmentally-programmed celular senescence is conserved and widespread in zebrafish.

  Da Silva-Álvarez S., Guerra-Varela J., Sobrido-Cameán D., Quelle A., Barreiro-Iglesias A., Sánchez L. & Collado M.

  Aging, 12: 17895-17901. (https://doi.org/10.18632/aging.103968) 2020

   

  Modeling cancer using zebrafish xenografts: drawbacks for mimicking the human microenvironment.

  Cabezas-Sáinz P., Pensado-López A., Sáinz Jr. B. & Sánchez L.

  Cells, 9: 1978. (https://doi.org/10.3390/cells9091978) 2020

   

  Inhibition of gamma-secretase promotes axon regeneration after a complete spinal cord injury

  Sobrido-Cameán D., Robledo D., Romaus-Sanjurjo D., Pérez-Cedrón V., Sánchez L., Rodicio M.C. & Barrerio-Iglesias A.

  Frontiers in Cell & Developmental Biology, 8:173. (doi: 10.3389/fcell.2020.00173) 2020

   

  Looking for a better characterization of triple-negative breast cancer by means of circulating tumor cells

  Abreu M., Cabezas-Sáinz P., Pereira-Veiga T., Falo C., Abalo A., Morilla I., Curiel J., Cueva, J., Rodríguez C., Varela-Pose V., Lago-Lestón R., Mondelo P., Palacios P., Moreno-Bueno G., Cano A., García-Caballero T., Pujana M.A., Sánchez-Piñón L., Costa C., López R.  & Muinelo-Romay L.

  Journal of Clinical Medicine, 9: 353 (doi.org/10.3390/jcm9020353) 2020

   

  Acetaminophen affects the survivor, pigmentation and development of craniofacial structures in zebrafish (Danio rerio) embryos

  Cedrón V.P., Weiner A., Vera M. & Sánchez L.

  Biochemical Pharmacology, 174: 113816 (doi.org/10.1016/j.bcp.2020.113816) 2020

   

  Cell senescence contributes to tissue regeneration in zebrafish.

  Da Silva-Álvarez S., Guerra-Varela J., Barreiro-Iglesias A., Sánchez L. & Collado M.

  Aging Cell, 19: e13052 (doi.org/10.1111/acel.13052) 2020

   

  Danio rerio as model organism for adenoviral vector evaluation

  Gulías P., Guerra-Varela J., González-Aparicio M., Ricobaraza A., Vales A., González-Aseguinolaza G., Hernández-Alcoceba R. & Sánchez L.

  Genes, 10: 1053 (doi: 10.3390/genes10121053) 2019

   

  The development of cell senescence

  Da Silva-Álvarez S., Picallos-Rabina p., Antelo-Iglesias L., Triana-Martínez F., Barreiro-Iglesias A., Sánchez l.E. & Collado M.

  Experimental Gerontology, 128: 110742 (doi.org/10.1016/j.exger.2019.110742) 2019

   

  The size and composition of polymeric nanocapsules dictate their interaction with macrophages and biodistribution in zebrafish.

  Crecente-Campo J., Guerra-Varela J., Peleteiro M., Gutiérrez-Lovera C., Fernández-Mariño I., Diéguez-Docampo A., González-Fernández A., Sánchez L. & Alonso M.J.

  Journal of Controlled Release 308: 98-108 (doi.org/10.1016/j.jconrel.2019.07.011) 2019

   

  POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages.

  Seoane S., Martínez-Ordóñez A., Eiro N., Cabezas-Sáinz P., García-Caballero L., González L.O., Sánchez L., Vizoso F. & Pérez-Fernández R.

  Journal of Pathology, 249: 381-394 (doi: 10.1002/path.5324) 2019

   

  In vivo toxicity assays in zebrafish embryos as a pre-requisit in a xenograft preclinical studies

  Gutiérrez-Lovera C., Martínez-Val J., Cabezas-Sáinz P., López R., Rubiolo J.A. & Sánchez L.

  Toxicology Mechanisms & Methods, 29: 478-487 (doi: 10.1080/15376516.2019.1611980) 2019

   

  Serotonin inhibits axonal regeneration of identificable descending neurons after a complete spinal cord injury in lampreys

  Sobrido-Cameán D., Robledo D., Sánchez L., Rodicio M.C. & Barreiro-Iglesias A.

  Diseases Models and Mechanism, 12: dmm037085. (doi: 10.1242/dmm.037085) 2019

   

  CTCs-derived xenograft development in a Triple Negative breast cancer case

  Pereira-Veiga T., Abreu M., Robledo D., Matias-Guiu X., Santacana M., Sánchez L., Cueva J., Palacios P., Abdulkader I., López-López R., Muinelo-Romay L. & Costa C.

  International Journal of Cancer 144: 2254-2265. (doi: 10.1002/ijc.32001)2019

   

  Glycosylated cell penetrating peptides GCPPs.

  Gallego I., Rioboo A., Reina J.J., Díaz B., Canales-Mayordomo A., Cañada J., Guerra-Varela J., Sánchez L. & Montenegro J.

  ChemBiochem, 20: 1400-1409 (doi.org/10.1002/cbic.201800720) 2019

   

  Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation

  Ikonomopoulou M.P., Pineda S.S., Fernández-Rojo M.A., Cabezas-Sáinz P., Winnen B., Morales R.A.V., Brust A., Sánchez L.E., Alewood P., Ramm G.A., Miles J.J. & King G.F.

  Scientific Reports  8: 11519. (doi: 10.1038/s41598-018-29826-4) 2018

   

  First description of a natural infection with spleen and kidney necrosis virus in zebrafish

  Bermúdez R., Losada A.P., de Azevedo A.M., Guerra-Varela J., Pérez-Fernández D., Sánchez L., Padrós F., Nowak B. & Quiroga M.I.

  Journal of Fish Diseases, 41: 1283-1294 (doi: 10.1111/jfd.12822) 2018

   

  Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis

  Martínez Ordóñez-A., Seoane S., Cabezas-Sáinz P., Eiro N., Sendón-Lago J., Macía M., García Caballero T., González L.O., Sánchez L., Vizoso F. & Pérez-Fernández R.

  Oncogene, 37: 1430-1444 (doi: 10.1038/s41388-017-0036-8). 2018

   

  Susceptibility of zebrafish  to Vesicular Stomatitis Virus infection

  Guerra-Varela J., Baz-Martínez M., Da Silva-Álvarez S., Losada A.P., Quiroga M.I., Collado M., Rivas C. & Sánchez L.

  Zebrafish, 15: 124-132 (doi: 10.1089/zeb.2017.1499). 2018

   

  Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing proliferation index with ZFtool.

  Cabezas-Sáinz P., Guerra-Varela J., Carreira M.J., Mariscal J., Roel M., Rubiolo J.A., Sciara A.A., Abal M., Botana L.M., López R. & Sánchez L.

  BMC Cancer, 18:3 (10.1186/s12885-017-3919-8). 2018

   

  Assessment of the permeability and toxicity of polymeric nanocapsules using the zebrafish model

  Teijeiro-Valiño C., Yebra-Pimentel E., Guerra-Varela J., Csaba N., Alonso M.A. & Sánchez L.

  Nanomedicine, 12: 2069-2082  (doi: 10.2217/nnm-2017-0078). 2017

   

  Dinuclear RuII(bipy)2 derivatives: structural, biological, and in vivo zebrafish toxicity evaluation.

  Lenis-Rojas O.A., Cabral R., Carvalho B., Friães S., Roma-Rodrigues C., Araujo Fernández J.A., Fernández-Vila S., Sánchez L., Gomes C.S.B., Fernandes A.R., Fernandes A.R. & Royo B. 2021. Triazole-based half-sandwich ruthenium(II) compounds: from in vitro antiproliferative potential to in vivo toxicity evaluation.

  Inorganic Chemistry, 60: 8011-8026. (doi: 10.1021/acs.inorgchem.1c00527).

   

  The potential of zebrafish for improving the translation of genetic anticancer nanomedicines

  Gutiérrez-Lovera C., Vázquez-Ríos A., Guerra-Varela J., Sánchez L. & de la Fuente M.

  Genes 8: 349 (doi:10.3390/genes8120349). 2017

   

  Heteroleptic mononuclear compounds of ruthenium (II): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos.

  Lenis-Rojas O.A., Fernandes A.R., Roma-Rodrigues C., Baptista P.V., Marques F., Pérez-Fernández D., Guerra-Varela J., Sánchez L., Vázquez-García D., López Torres M., Fernández A. & Fernández J.J.

  Dalton Transactions, 45: 19127-19140 (doi: 10.1039/C6DT03591D). 2016

   

  Cell senescence is an antiviral defense mechanism.

  Baz-Martínez M., Da Silva-Álvarez S., Rodríguez E., Guerra J., El Motiam A., Vidal A., García-Caballero T., González-Barcia M., Sánchez L., Muñoz-Fontela C., Collado M. & Rivas C.

  Scientific Reports, 6: 37007. (doi:10.1038/srep37007). 2016

   

  Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model.

  Roel M., Rubiolo J.A., Guerra-Varela J., Silva Siguara B. L., Thomas O.P., Cabezas-Sainz P., López R., Sánchez L. & Botana L.M.

  Oncotarget, 7: 83071-83087. (doi: 10.18632/oncotarget.13068). 2016

   

  “A zebra in the water”: Inspiring science in Spain.

  Guerra-Varela J., Cabezas-Sáinz P., Yebra-Pimentel E., Gutiérrez-Lovera C., Cedrón V.P., Otero Obarrio M.A., Sciara A.A., Rodríguez N., Araujo J., Millán A. & Sánchez L.

  Zebrafish, 13(4): 241-247. (doi:10.1089/zeb.2015.1178). 2016

   

  Light-controlled celular internalization and cytotoxicity of nucleic acid-binding agents. Studies in vitro and in zebrafish embryos.

  Penas C., Sánchez M.I., Guerra-Varela J., Sánchez L., Vázquez M.E. & Mascareñas J.L.

  ChemBioChem, 17: 37-41. (doi: 10.1002/cbic.201500455). 2016